MTMMetabolism and Translational Medicine2958-8081 (Online)Porcelain Publishinghttps://doi.org/10.54844/mtm.2023.0422Articlehttps://artdesignp.com/journal/MTM/3/2/https://doi.org/10.54844/mtm.2023.0422FeiMin,GuoYansong,WangHuiqing,LinNan321970-01-01Many human diseases are associated with hyperactivity of platelet metabolism. Understanding in detail the connection between metabolic changes and platelet activation state is an indispensable part of thrombosis treatment. This review describes changes in the energy metabolism of platelets during thrombosis and their potential molecular mechanisms. The metabolic flexibility of energy substrate selection in activated platelets is discussed briefly, along with strategies by which platelet activation and thrombosis formation can be blocked by targeting activated platelet metabolism.thrombosis, platelets, glycolysis, fatty acid metabolism, amino acid metabolism